Monday, 12 October 2015

08:30 - 10:45     Session 4A: Adaptive Immunity – Cellular                                       Salle Erasme
                          Session chairs: Robert THIMME & Georg M LAUER

08:30 – 09:00 Plenary lecture: Mala MAINI

Mala MainiInnate regulation of adaptive immunity in the HBV-infected liver
Mala MAINI, PhD, FRCP, Professor and Honorary Consultant, Viral Immunology, Wellcome Trust Senior Investigator, Deputy Head, Department of Immunology, Division of Infection and Immunity UCL, London, UK

Mala Maini is a Professor of Viral Immunology in the Division of Infection and Immunity at UCL, Deputy Head of Department and Honorary Consultant Physician in the viral hepatitis clinic. In addition she recently led the successful Divisional application for an Athena SWAN Silver award.
After completing her specialist medical accreditation in 1995 she obtained an MRC Clinical Training Fellowship, leading to a PhD on T cell clonality and senescence in 1998. In 2002 she was awarded an MRC/Academy of Medical Sciences Tenure-track Clinician Scientist Fellowship, and built up her own group working on the immunopathogenesis of hepatitis B. In 2009 she was promoted to a Personal Chair and in 2013 awarded a Wellcome Trust Senior Investigator Award. Her lab is at the forefront internationally of research on the immunology of hepatitis B.  In addition to their work dissecting defects in adaptive immune control of HBV (Lopes et al. JCI 2008, Das et al. JEM 2008, Schurich et al. Hepatol 2011, Das et al. JI 2012, Schurich et al. PLoS Path 2013), they have made a number of seminal contributions to defining the role of NK cells and myeloid-derived suppressor cells in regulating immunity and immunopathology (Dunn JEM 2007, Dunn Gastro 2009, Peppa PLoS Path 2011, Micco J Hepat 2012, Peppa JEM 2013, Pallett Nat Med 2015).

 

09:00 - 09:15     Primer Adaptive Immunity
                          Barbara REHERMANN, NIH NIDDK, Bethesda, MD, USA

09:15 - 10:45 Session 4A oral abstracts

09:15 - 09:30 Follicular T helper cell signatures on virus-specific CD4 T cells during acute and chronic HCV infection 04.01
  Bijan RAZIORROUH, Kathrin SACHER, Rajiv G Tawar, Florian EMMERICH, Christoph NEUMANN-HAEFELIN, Thomas F BAUMERT, Robert THIMME, Tobias BOETTLER  
09:30 - 09:45 Integrative analysis of CD8 T-cell responses in the context of adaptive immunity to acute hepatitis C virus infection
04.02
  David WOLSKI, Catherine FAUVELLE, Diana CHEN, Peter FOOTE, Pierre TONNERRE, Deyong GAO, Lyndon MATSUBARA, Brandon ROBILOTTI, Jasneet ANEJA, Stephanie KULAGA, Michaela SUPERSON, Joelle BROWN, Lia LEWIS-XIMENEZ, Arthur KIM, Thomas F BAUMERT, Georg M LAUER  
09:45 - 10:00 Transcriptomic characterization of the immune response to acute hepatitis C virus infection
04.03
  Brad R ROSENBERG, Marion DEPLA, Catherine A FREIJE, Denis GAUCHER, Nathalie BEDARD, Julie BRUNEAU, Charles M RICE, Naglaa H SHOUKRY  
10:00 - 10:15 TGF-beta-mediated Smad3 enhances PD-1 expression on antigen-specific T cells
04.04
  Benjamin PARK, Michael CHATTERGOON, Alleluiah RUTEBEMBERWA, Jordana STEIGNER, Matthew WINTER, Suzanne SEBALD, Se-Jin LEE, Fan PAN, Drew PARDOLL, Andrea COX  
10:15 - 10:30 Restoration of HCV-specific CD8+ T cells during IFN-free therapy 04.05
  Dominik WIELAND, Maike HOFMANN, Bianca MARTIN, Hendrik LUXENBURGER, Christoph NEUMANN-HAEFELIN, Robert THIMME  
10:30 - 10:45 Cross-reactive HLA-B*27-restricted CD8+ T cells are associated with a protective effect against HCV genotypes 1 and 3 in highly-exposed individuals 04.06
  Kathrin SKIBBE, Bettina BUDEUS, Andreas WALKER, Katja NITSCHKE, Falko HEINEMANN, Peter HORN, Wim VAN ESCH, Katrin FROHNMÜLLER, Christoph NEUMANN-HAEFELIN, Norbert SCHERBAUM, Daniel HOFFMANN, Jörg TIMM  

 

10:45 - 11:15     Refreshment Break                                                                          Forum

11:15 - 12:00     Session 4B: Adaptive Immunity: Humoral
                          Session chairs: Steven KH FOUNG & Jens BUKH

11:15 - 12:00 Session 4B oral abstracts

11:15 - 11:30 Structural dynamics in the central domain of the hepatitis C virus glycoprotein E2 04.07
  Ieva VASILIAUSKAITE, Ania OWSIANKA, Patrick ENGLAND, Weronika WITKOWSKA, Steven K H FOUNG, Rachael SWANN, Felix A REY, Arvind H PATEL, Thomas KREY  
11:30 - 11:45 Spontaneous clearers with high-risk behaviors are protected from reinfection or subsequent chronic infection by broadly neutralizing antibodies
04.08
  Sabrina J MERAT, Richard MOLENKAMP, Dorien VAN DE BERG, Camille BRU, Sylvie KOEKKOEK, Maria PRINS, Arjen Q BAKKER, Menno D DE JONG, Hergen SPITS, Tim BEAUMONT, Janke SCHINKEL  
11:45 - 12:00 The neutralizing antibody response profile in a subject that spontaneously cleared multiple HCV infections
04.09
  Zhenyong KECK, Rowena BULL, Fabio LUCIANI, Elizabeth KEOSHKERIAN, Catherine FAUVELLE, Thomas F BAUMERT, Andrew LLOYD, Steven KH Foung  

 

12:00 - 13:00     Session 4C: Adaptive Immunity: Vaccines
                          Session chairs: Steven KH FOUNG & Jens BUKH

12:15 - 13:00 Session 4C oral abstracts

12:00 - 12:15 Neutralizing antibody induction by vaccination of cell culture-generated hepatitis C virus particles in non-human primate model 04.10
  Hiroshi YOKOKAWA, Atsunori HIGASHINO, Saori SUZUKI, Tomohiko SUZUKI, Hirofumi AKARI, Takanobu KATO, Koji ISHII, Takaji WAKITA  
12:15 - 12:30 Investigating the mechanisms of action of neutralizing antibody responses elicited by a recombinant hepatitis C virus envelope glycoprotein E1E2 vaccine
04.11
  Jason Alexander Ji-Xhin WONG, Darren HOCKMAN, Aviad LEVIN, Janelle JOHNSON, Joseph MARCOTRIGIANO, D Lorne Tyrrell, John Lok Man LAW, Michael HOUGHTON  
12:30 - 12:45 Immunization with a single recombinant hepatitis C virus envelope protein elicits pan-genotypic neutralizing antibodies in macaques and confers protection against viral challenge in mice
04.12
  Dapeng LI, Markus VON SCHAEWEN, Xuesong WANG, Alexander PLOSS, Jin ZHONG, Zhong HUANG  
12:45 - 13:00 Protection against hepatitis C virus in a syngenic transplantation mouse model 04.13
  Matti SÄLLBERG, Lars FRELIN, Sepideh LEVANDER, Fredik HOLMSTRÖM, Gang LONG, Daniel RUPP, Ralf BARTENSCHLAGER  

 

13:00 - 14:30     Lunch                                                                                               Galerie de Marbre

14:30 - 16:15     Session 5A: Related viruses – Dengue
                          Session chairs: Stéphane Bressanelli & Jean DUBUISSON

14:30 – 15:00 Plenary lecture: Michael DIAMOND

Michael DiamondNew mechanisms of antiviral control by interferon-lambda
Michael DIAMOND, MD, PhD, Professor, Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Head, Division of Infectious Diseases and Vaccine Development, Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA

Prof. Michael Diamond received his M.D. and Ph.D. from Harvard University (USA), and his post-doctoral and clinical training in infectious diseases and virology from the University of California, Berkeley and the University of California, San Francisco (USA). He is currently a Professor of Medicine, Molecular Microbiology, Pathology & Immunology at Washington University School of Medicine (USA) and the Associate Director of the Center for Human Immunology and Immunotherapy Programs. Prof. Diamond’s laboratory studies the molecular basis of disease of globally important RNA viruses (e.g., West Nile (WNV), dengue, and chikungunya viruses), and focuses on pathogenesis and host immunity. For WNV, his group identified the key immune system components that orchestrate protection in vivo, which had provided a new understanding of the temporal and tissue-specific immune responses that restrict infection. Among his additional achievements are his studies defining how antibodies protect against viruses. This work has provided new insight into how virus neutralization occurs at the structural and molecular level and has defined the unique functions of different memory B cells, led to development of therapeutic antibodies, and generated new models of viral pathogenesis.

 

15:00 - 16:15 Session 5A oral abstracts

15:00 - 15:15 Architecture of the dengue virus NS5 and consequences for its RNA polymerase and methyltransferase functions 05.01
  Cyntia TAVENEAU, Maria J MATÉ, Anil KUMAR, Lionel BEAUREPAIRE, Barbara SELISKO, Isabelle VARLET, Ralf BARTENSCHLAGER, Bruno CANARD, Stéphane BRESSANELLI  
15:15 - 15:30 Dengue virus non-structural protein 1 modulates infectious particle production via interaction with the structural proteins
05.01
  Pietro SCATURRO, Mirko CORTESE, Laurent CHATEL-CHAIX, Wolfgang FISCHL, Ralf BARTENSCHLAGER  
15:30 - 15:45 Dengue virus infection of human stem cell-derived hepatic cells is self-limiting, activates innate immunity and partial dedifferentiation
05.01
  Jianshe LANG, Daniel VERA, Yichen CHENG, Hengli TANG  
15:45 - 16:00 AAK1 and GAK regulate intracellular viral trafficking and are potential targets for treatment of dengue and other emerging viral infections 05.01
  Elena BEKERMAN, Gregory NEVEU, Szuyuan PUE, Jennifer BRANNAN, Ana SHULLA, Jennifer GOVERO, Michael DIAMOND, Glenn RANDALL, John DYE, Shirit EINAV  
16:00 - 16:15 A high-content siRNA screen identifies host cell factors involved in the DENV replication cycle and potential targets for antiviral therapy 05.01
  Eliana G ACOSTA, Wolfgang FISCHL, Alessia RUGGIERI, Chris LAUBER, Lars KADERALI, Holger ERFLE, Ralf BARTENSCHLAGER  

 

16:15 - 16:45     Refreshment Break                                                                           Forum

16:45 - 17:45     Session 5B: Related viruses – other
                          Session chairs: Philip MEULEMAN & Norbert TAUTZ

16:45 - 17:45 Session 5B oral abstracts

16:45 - 17:00 Bacterial effectors as cell biological probes to study Flaviviridae replication 05.06
  Harish RAMANATHAN, Brett LINDENBACH  
17:00 - 17:15 Morphology and molecular composition of purified BVDV particles
05.07
  Nathalie CALLENS, Britta BRUEGGER, Pierre BONNAFOUS, Herve DROBECQ, Thomas KREY, Till RUEMENAPF, Olivier LAMBERT, Jean DUBUISSON, Yves ROUILLÉ  
17:15 - 17:30 The pestiviral NS4A kink domain is a dynamic regulator of RNA replication and virion morphogenesis
05.08
  Danilo DUBRAU, Maria Alejandra TORTORICI, Oliver KLEMENS, Felix A Rey, Norbert TAUTZ  
17:30 - 17:45 Persistent replication of the hepatitis E virus infection in rhesus macaques after antibody-mediated depletion of CD4+ T cells 05.09
  Roxane ALLES, Heather ECCLESTON, Bill BREMER, Vikas SAXENA, Christopher WALKER  

 

20:00                 HCV 2015 GALA                                                                               Palais Universitaire

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20:00                 HCV 2015 PARTY                                                                             Barco Latino