Tuesday, 13 October 2015

09:00 - 11:00     Session 6: Innate Immunity                                                            Salle Erasme
                          Session chairs: Marlène DREUX & Yoshiharu MATSUURA

009:00 – 09:30 Plenary lecture: Percy KNOLLE

Percy KnolleRegulation of antiviral immunity in the liver
Percy KNOLLE, MD, PhD, Director of the Institutes of Molecular Immunology and Experimental Oncology at TUM Medical Faculty and at the TUM School of Life Sciences Weihenstephan at Technische Universität, Munich, Germany

Prof. Knolle studied medicine at the Universities of Frankfurt, Paris, Birmingham (UK), Strasbourg, and Geneva and completed his MD thesis at the German Cancer Research Center (Applied Immunology, Prof. Meuer) in 1990 in Heidelberg. After a postdoctoral fellowship with the Bioresearch Corporation of BASF Cambridge (USA) he joined the 1st Medical Department at University of Mainz, Germany (Prof. Meyer zum Büschenfelde) in 1991 as a physician. There he obtained his qualification as specialist in Internal Medicine in 1997. From 1997 until 2002 Prof. Knolle held the position of an independent junior group leader at the Center of Molecular Biology in Heidelberg, Germany (ZMBH). During this period the Volkswagenstiftung granted him a Research Award (1.5 Million €). In 2002 he joined the University of Bonn (Germany) as full professor and was appointed founding director of the Institutes of Molecular Medicine and Experimental Immunology (IMMEI). Prof. Knolle accepted a full professorship at Technische Universität in Munich in 2013 and remains co-opted Professor of Molecular Medicine at the University of Bonn. Prof. Knolle holds several academic positions and is a member of the German Society of Immunology and the German Association for the Study of the Liver.

09:30 - 11:00 Session 6 oral abstracts

09:30 - 09:45 The extent of monocyte-induced activation of NK cells is dependent on the IL28B genotype in
HCV(+) patients
  Benjamin KRÄMER, Beatriz Sara SASTRE TURRION, Claudia FINNEMANN, Andreas GLÄSSNER, Franziska WOLTER, Pavlos KOKORDELIS, Dominik KACZMAREK, Philipp LUTZ, Felix GOESER, Ulrich SPENGLER, Jacob NATTERMANN  
09:45 - 10:00 Individuals resistant to HCV infection are characterized by activated NK cells
  Maggie MG OW, Daniel J FELMLEE, Doha HEGAZY, Usama WARSHOW, Matthew E CRAMP  
10:00 - 10:15 Hepatitis C virus infection remodels the Golgi complex to trigger autophagy through the immunity-related GTPase M
  Marianne Doré HANSEN, Ingvild JOHNSEN, Kim STIBERG, Jostein MALMO, Eliane MEURS, Marit ANTHONSEN  
10:15 - 10:30 MicroRNA-373 impairs signaling pathways for establishment of hepatitis C virus Infection
  Shubham SHRIVASTAVA, Anupam MUKHERJEE, Adrian DI BISCEGLIE, Ranjit RAY, Ratna RAY  
10:30 - 10:45 The role of LGP2 in HCV infection induced RLRs mediated IFN signaling 06.05
  Lei HEI, Jin ZHONG  
10:45 - 11:00 Secretion of hepatitis C virus replication intermediates reduces activation of TLR3 response in hepatocytes 06.06
  Oliver GRÜNVOGEL, Volker KLÖSS, Inès ROMERO-BREY, Katharina ESSER-NOBIS, Alexander DALPKE, Volker LOHMANN  


11:00 - 11:30     Refreshment Break                                                                          Galerie de Marbre

11:30 – 12:00 Keynote lecture: Charles M RICE

Charles RiceHepatitis C virus and beyond
Charles M RICE, PhD, Maurice R and Corinne P Greenberg Professor, The Rockefeller University, Scientific and Executive Director, Center for the Study of Hepatitis C, New York City, NY, USA

Prof. Rice is the Head of the Laboratory for Virology and Infectious Disease at the Rockefeller University. He is a prominent figure in research on members of the Flaviviridae including hepatitis C virus. Prof. Rice received his bachelor’s degree from University of California Davis in 1974 and earned his Ph.D. from California Institute of Technology in 1981. From 1986-2000, Prof. Rice was a faculty member at Washington University in St. Louis.  Prof. Rice has co-authored over 400 articles in the field of virology, serves as a reviewer for numerous journals, is a past President of the American Society for Virology, a Fellow of the American Association for the Advancement of Science, and a Member of the National Academy of Sciences.


12:00 - 12:05     Closing remarks
                          Michael HOUGHTON

12:05 - 12:10     HCV 2016 KYOTO
                          Yoshiharu MATSUURA

12:10 - 12:15     Farewell
                          Robert THIMME – Jean DUBUISSON